The Method is the Message: Communicating for Individual Behavior Change Toward Disciple Multiplication

The purpose of this ethnographically informed, comparative embedded case study was to understand the lack of disciple-making movements for congregations at three evangelical churches representing the East Coast, Midwest, and West Coast of the United States. The theories guiding this study were Latour’s actor–network theory and Bandura’s social cognitive theory as they provide a theoretical framework to understand the influence of culture on the creation of meaning followed by the influence of meaning on individual behavior. The primary research question that guided this study asked, How can a church organization communicate to increase disciple multiplication? To answer this question, a qualitative approach was used with data collected through site visits to the three participating sites, a digital media review, an artifact review, and 75 personal interviews, with 25 interviews from each of the three participating churches. Data from each method were descriptively coded, inferentially coded, and then analyzed for patterns and themes. Overall results found substantial cultural influence on the organizational culture of all three churches, with a common theme of commercialism throughout all three sites. Despite unique organizational visions and rhetoric, nearly identical methodological approaches to core functions of the organizations existed between the three sites. The methodological approaches to disciple -making at all three sites failed to engage elements of social cognitive theory that are proven to influence individual behavior change. The primary recommendation from this study was to ontologically transform the organization’s methodological approach to disciple making to focus most of the organizational communication through small, intimate community with a narrow message focused on mission, predicated with a tangential model of expected behavior first provided by organizational leadership

Salesforce.com

Innovation! One of the most innovative companies, and also one of the best companies to work for, is losing money. This case traces the meteoric rise of the number one customer relationship management service provider against huge rivals such as Microsoft and Oracle. Detail regarding their highly innovative Scrum system is provided, along with detail regarding their marketing approach. How can Salesforce.com regain profitability while continuing to grow in a highly competitive industry

In Vitro and In Vivio Evaluation of a Moisture Treatment Cream Containing Three Critical Elements of Natural Skin Moisturization

Objectives To evaluate skin barrier and hydration effects of a new rebalancing moisture treatment (TRMT) and to assess efficacy and tolerability in subjects with photodamaged skin. Methods In an epidermal skin model, tissues (n = 5/group) were topically treated with 25 µL of TRMT, 25 µL of a market‐leading moisturizer (MLM), or untreated for 60 minutes. Hydration was measured at 0, 15, and 30 minutes. Tissues were harvested for gene expression analysis of markers associated with skin barrier and hydration: Claudin (CLD), Aquaporin (AQP), Hyaluronic Acid Syntheses (HAS), and Hyaluronidase (HYAL). A clinical study evaluated twice‐daily application of TRMT, assessing changes in fine lines/wrinkles, brightness, texture, erythema, and tolerability from baseline through week 8. Hydration was measured using electrical impedance. Results TRMT and MLM demonstrated significant increases in hydration vs untreated tissue at each timepoint (P \u3c .005), with greater hydration effects observed for TRMT vs MLM. TRMT‐treated tissues demonstrated greater expression of CLD, AQP, and HA, and reduced expression of HYAL vs untreated and MLM‐treated tissues. Twice‐daily application of TRMT demonstrated significant improvements at 2 weeks in fine lines/wrinkles (P \u3c .001), brightness (P \u3c .0001), texture (P \u3c .0004), and hydration (P \u3c .004). At 8 weeks, statistically significant improvements were achieved in all categories. Conclusion In an epidermal skin model, TRMT demonstrated significant increases in hydration, greater hydration effects, and expression of key markers associated with skin barrier and hydration vs a MLM. Twice‐daily application of TRMT was well tolerated and resulted in early, significant improvements in hydration and visible improvements in skin brightness, texture, fine lines/wrinkles, and erythema at 8 weeks

Scheduling and Fluid Routing for Flow-Based Microfluidic Laboratories-on-a-Chip

Microfluidic laboratories-on-a-chip (LoCs) are replacing the conventional biochemical analyzers and are able to integrate the necessary functions for biochemical analysis on-chip. There are several types of LoCs, each having its advantages and limitations. In this paper we are interested in flow-based LoCs, in which a continuous flow of liquid is manipulated using integrated microvalves. By combining several microvalves, more complex units, such as micropumps, switches, mixers, and multiplexers, can be built. We consider that the architecture of the LoC is given, and we are interested in synthesizing an implementation, consisting of the binding of operations in the application to the functional units of the architecture, the scheduling of operations and the routing and scheduling of the fluid flows, such that the application completion time is minimized. To solve this problem, we propose a list scheduling-based application mapping (LSAM) framework and evaluate it by using real-life as well as synthetic benchmarks. When biochemical applications contain fluids that may adsorb on the substrate on which they are transported, the solution is to use rinsing operations for contamination avoidance. Hence, we also propose a rinsing heuristic, which has been integrated in the LSAM framework

Applying Publicly Available Contextual Factors to Predict Smoking Relapse in a National Sample

Background: The ecological fallacy is broadly understood, though its complimentary problem, the individualistic or atomistic fallacy, isless often considered. Multilevel models offer the statistical tools needed to avoid both errors by allowing simultaneous considerationof individual, contextual, and policy factors. This study applies such methods to smoking cessation data. Tobacco control is of particularconcern in Ohio where the adult smoking prevalence remains around 22%.Methods: Data from the 1,785 participants in the Technology Enhanced Quitline Study were used to test the theory that contextualfactors impact relapse rates and program effectiveness, employing a mixed-effects model to account for the nested nature of the datawhile testing for the relationship between contextual factors and relapse, controlling for individual characteristics.Results: No contextual factors or policy variables were significant predictors of smoking relapse in the sample, nor were any associated with the success of the intervention.Conclusions: While this work could not identify specific influences of contextual and policy factors on smoking outcomes in our sample, it demonstrates the feasibility of adding such predictors to future clinical trials. This project clearly does not rule out the possibility that contextual and policy factors may influence smoking even after controlling for individual characteristics, but does not provide strong evidence of such a link. It is possible that these negative findings may be due to geocoded mailing addresses being a poor proxy for relevant contextual factors, use of the wrong geographic unit of analysis (modifiable areal unit problem), or a lack of temporal resolution in contextual variables

Panel. Community Engagement and Interpreting Slavery in North Mississippi

The “Behind the Big House” Project / Jodi Skipper, University of Mississippi and Suzanne DavidsonBehind the Big House is a slave dwelling interpretation program in Holly Springs, Mississippi. The program offers a counter-narrative to the Holly Springs Annual Pilgrimage Tour of Historic Homes and Churches, the city’s main tourist attraction which has historically neglected the contributions of enslaved persons. Behind the Big House was initiated by several private property owners who understood that interpreting the structures which housed enslaved persons could help to remedy such omissions. In addition to discussing how historical memory impacts the functions of these sites in the present, Skipper will discuss her role as a Behind the Big House tour guide, and how she incorporates the tour as an applied component in her courses. Slavery and Its Descendants / W. Ralph Eubanks, University of MississippiThe legacy of slavery and its impact across generations of African Americans is often ignored or overlooked, particularly by institutions that benefited from enslaved labor. The University of Mississippi is no exception. Payment records from the 1840s in the archives of the University of Mississippi indicate that Robert Sheegog—who once owned Faulkner’s home Rowan Oak—along with other local slave owners, loaned slaves to the University. This connection between the slaves of Rowan Oak and the building of the University of Mississippi holds the potential to redefine the idea of legacy connections to the University, since inevitably the descendants of several of those slaves are among the university’s alumni. This paper will discuss the on-going work of the University of Mississippi’s slavery research group and the possible outcomes of planned genealogical research to find the descendants of the slaves from Faulkner’s Rowan Oak who built the university.The University of Mississippi Slavery Research Group / Jeffrey Jackson and Charles K. Ross, University of MississippiIn this presentation, we present the story of the University of Mississippi Slavery Research Group focusing on its origins and the various factors that led to its formation. We highlight some of the groups’ most significant recent efforts to better understand how antebellum slavery shaped the formation of the University of Mississippi and life in North Mississippi generally and we discuss some of our initial projects and initiatives that seek to remember, memorialize and interpret the lives of enslaved people for our students, our local community, and our nation.Interpreting Slavery at Burns Belfry and Rowan Oak / George McDaniel, Burns-Belfry African American History MuseumCaroline Barr was a foundational figure in the life of William Faulkner. As he called her, “Mammy Callie,” she had worked for the Falkner family since he was a young boy. Her house and her story demand a further interpretation beyond the gates of Rowan Oak. Using her as a point of departure, this talk will explore African American history within the larger context of the town of Oxford. It will also look at the ways in which that history is being interpreted today and how that interpretation can be improved through building connections between different historical sites. This connectivity allows for a deeper understanding of African American history in Oxford and the world in which Faulkner lived and wrote

Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations

BACKGROUND: A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs. OBJECTIVE: To determine whether inflammatory genetic markers could stratify patients with knee OA into high and low risk for destructive disease. METHODS: Genotype associations with knee OA severity were assessed in two Caucasian populations. Fifteen single nucleotide polymorphisms (SNPs) in six inflammatory genes were evaluated for association with radiographic severity and with synovial fluid mediators in a subset of the patients. RESULTS: Interleukin 1 receptor antagonist (IL1RN) SNPs (rs419598, rs315952 and rs9005) predicted Kellgren-Lawrence scores independently in each population. One IL1RN haplotype was associated with lower odds of radiographic severity (OR=0.15; 95% CI 0.065 to 0.349; p<0.0001), greater joint space width and lower synovial fluid cytokine levels. Carriage of the IL1RN haplotype influenced the age relationship with severity. CONCLUSION: IL1RN polymorphisms reproducibly contribute to disease severity in knee OA and may be useful biomarkers for patient selection in disease-modifying OA drug trials

A computational reconstruction of Papio phylogeny using Alu insertion polymorphisms

© 2018 The Author(s). Background: Since the completion of the human genome project, the diversity of genome sequencing data produced for non-human primates has increased exponentially. Papio baboons are well-established biological models for studying human biology and evolution. Despite substantial interest in the evolution of Papio, the systematics of these species has been widely debated, and the evolutionary history of Papio diversity is not fully understood. Alu elements are primate-specific transposable elements with a well-documented mutation/insertion mechanism and the capacity for resolving controversial phylogenetic relationships. In this study, we conducted a whole genome analysis of Alu insertion polymorphisms unique to the Papio lineage. To complete these analyses, we created a computational algorithm to identify novel Alu insertions in next-generation sequencing data. Results: We identified 187,379 Alu insertions present in the Papio lineage, yet absent from M. mulatta [Mmul8.0.1]. These elements were characterized using genomic data sequenced from a panel of twelve Papio baboons: two from each of the six extant Papio species. These data were used to construct a whole genome Alu-based phylogeny of Papio baboons. The resulting cladogram fully-resolved relationships within Papio. Conclusions: These data represent the most comprehensive Alu-based phylogenetic reconstruction reported to date. In addition, this study produces the first fully resolved Alu-based phylogeny of Papio baboons

Papio baboon species indicative Alu elements

© The Author(s) 2017. The genus of Papio (baboon) has six recognized species separated into Northern and Southern clades, each comprised of three species distributed across the African continent. Geographic origin and phenotypic variants such as coat color and body size have commonly been used to identify different species. The existence ofmultiple hybrid zones, both ancient and current, have complicated efforts to characterize the phylogeny of Papio baboons. More recently, mitochondrial DNA (mtDNA) and Y-chromosome genetic markers have been utilized for species identification with particular focus on the hybrid zones. Alu elements accumulate in a random manner and are a novel source of identical by descent variation with known ancestral states for inferring population genetic and phylogenetic relationships. As part of the Baboon Genome Analysis Consortium, we assembled an Alu insertion polymorphism database of nearly 500 Papio-lineage specific insertions representing all six species and performed population structure and phylogenetic analyses. In this study, we have selected a subset of 48 species indicative Alu insertions and demonstrate their utility as genetic systems for the identification of baboon species within Papio. Individual elements from the panel are easy to genotype and can be used in a hierarchical fashion based on the original level of uncertainty. This Alu-48 panel should serve as a valuable tool during the maintenance of pedigree records in captive populations and assist in the forensic identification of fossils and potential hybrids in the wild